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Description – Amifostine Amifostine is a broad-spectrum radio- and chemoprotector. It restores transcriptional activity of specific p53 mutants, prevents chemotherapy-induced apoptosis and upregulates HIF-1α. Amifostine offers a selective protection to normal cells over tumor cells due to normal cells having a 275-fold greater concentration of alkaline phosphatase, by reducing renal toxicity, higher pH and better vascularity of the normal tissue. …
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